Depression:
Symptoms, Severity Levels & Treatment

At a glance

FrequencyOne of the most common mental illnesses — around one in five to six people develops it over their lifetime, women roughly twice as often as men
Other namesDepressive episode, depressive disorder, unipolar depression, "major depression"
Key symptomLow mood, loss of interest and lack of drive for at least two weeks — not just a passing low
DiagnosisA medical or psychotherapeutic consultation based on fixed criteria — no blood test, no imaging
First lineDepending on severity: active monitoring, psychotherapy, antidepressants or a combination
ICD-10F32.9 (single episode), F33.9 (recurrent)

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1. What is depression?

Depression is a serious but very treatable illness — not a character flaw and not a passing low mood. It affects how you feel, how you think and how your body functions. Unlike normal sadness, which comes after a stressful event and passes again, depression lasts for at least two weeks, weighs on your mood almost continuously and cannot simply be "shaken off" or dissolved by a pleasant moment.

Central to it is a trio of three complaints: a low, downcast mood, a loss of interest and pleasure in things that used to matter, and a lack of drive and energy that turns even simple everyday tasks into an effort. These three are called the core symptoms. They are at the heart of every diagnosis.

It is important to understand: depression is not "all in your head". It goes hand in hand with measurable changes in the regulation of neurotransmitters and stress systems in the brain and often shows up physically first — as a sleep disturbance, loss of appetite, pressure on the chest or persistent fatigue. Men and older people in particular more often report such physical complaints rather than sadness. This is precisely why depression sometimes goes unrecognised for a long time.

The good news Depression is one of the mental illnesses that can be treated best. With psychotherapy, medication or a combination, the symptoms improve markedly in most people — even if the illness feels hopeless right now. This very feeling of hopelessness is itself a symptom, not a verdict on your future.

2. Severity levels & forms

Not all depression is the same. What matters for treatment is how severe the episode is — because this determines whether to wait and see at first, begin psychotherapy or additionally use medication. The severity depends on how many of the core and additional symptoms are present and how strongly they limit everyday life.

SeveritySymptomsEveryday life
Mild2 core symptoms + 2 additional symptomsEveryday life still manageable, but with effort
Moderate2 core symptoms + 3–4 additional symptomsMarked limitation, many things are hard
Severe3 core symptoms + at least 4 additional symptomsEveryday life barely or no longer manageable
Table scrollable to the right

Alongside severity, there are different patterns of progression. In some people it remains a single episode (ICD-10 F32); in others the episodes recur over the course of life — this is then called a recurrent depressive disorder (F33). Common special forms:

  • Dysthymia: a milder but very long-lasting depressive mood over years.
  • Seasonal depression: episodes mainly in the dark time of year ("winter depression").
  • Postnatal depression: a depression in the weeks and months after a birth — it is common and very treatable.
  • Bipolar disorder: here depressive phases alternate with excessively elevated (manic) phases. It is treated differently from a pure (unipolar) depression — which is why the distinction is important.

3. Symptoms: core and additional symptoms

The diagnosis is based on a fixed pattern of core and additional symptoms that are present almost daily for at least two weeks. The three core symptoms form the foundation:

  • Low mood: persistent dejection, emptiness or hopelessness — often independent of the circumstances and worst in the morning.
  • Loss of interest and pleasure: things, hobbies or people that used to bring joy leave you cold. The technical term for this is anhedonia.
  • Lack of drive: quick exhaustion, leaden tiredness, the feeling of having no energy left for anything — even getting up or getting dressed can become a hurdle.

Added to these are the additional symptoms, which complete the picture and help determine the severity:

  • Problems with concentration and attention — thoughts feel sluggish, decisions are hard.
  • Reduced self-esteem and self-confidence.
  • Feelings of guilt and a sense of worthlessness.
  • Pessimistic, hopeless thoughts about the future.
  • Sleep disturbances — early waking in the morning is typical, but so are difficulties falling and staying asleep. More on this under sleep disorders.
  • Changes in appetite and weight — usually less appetite, more rarely more.
  • Thoughts of death or of taking one's own life.

Not everyone has all the symptoms, and they can present very differently. Some people seem sad and slowed down, others are restless and irritable. Many first report physical complaints — headaches or back pain, gastrointestinal problems, palpitations — behind which no organic problem can be found. This is then called a "larvate" (masked) depression.


4. Causes & risk factors

Depression rarely has a single cause. It arises from an interplay of biological, psychological and social factors — experts speak of a vulnerability-stress model: those who bring an increased vulnerability (for example through predisposition) are more likely to fall ill when additional burdens come on top. Importantly: no one is "to blame" for a depression.¹

  • Predisposition: depression tends to run in families. An affected parent increases your own risk.
  • Brain biochemistry: disrupted regulation of neurotransmitters such as serotonin and noradrenaline, as well as an overactive stress axis.
  • Stressful life events: loss, separation, unemployment, chronic overload or persistent stress.
  • Early experiences: neglect, violence or trauma in childhood.
  • Physical illnesses: such as an underactive thyroid, chronic pain, diabetes or stroke.
  • Certain medications and substances, as well as alcohol, which can worsen depression.
  • Social withdrawal and loneliness, which set a vicious circle in motion.

Often a situation does not tip over because of a single event, but through the coincidence of several factors over time. This also explains why a depression sometimes seems to come "out of the blue", even though outwardly everything appears fine. The biological vulnerability was already there — the burden was what made the barrel overflow.


5. Diagnosis & distinguishing it from burnout and anxiety

The diagnosis is made by a doctor or a psychotherapy professional in a consultation — based on the criteria named above, often supported by standardised questionnaires. There is no blood test and no imaging procedure that proves a depression. However, blood tests do serve to rule out physical causes such as an underactive thyroid or a vitamin deficiency, which can produce similar complaints.¹,²

Two distinctions often cause confusion:

Depression vs. burnout "Burnout" is not a medical diagnosis in its own right, but describes a state of exhaustion that is strongly tied to work and overload. Depression, by contrast, is a clearly defined illness that affects all areas of life — not just the job — and whose core is the loss of pleasure and drive. A persistent state of exhaustion can develop into a genuine depression. That is why, with "burnout" complaints, it is worth having a professional assessment of whether a depression requiring treatment lies behind it.

The second important distinction concerns anxiety disorder. Anxiety and depression often overlap and frequently occur together. The key difference: in an anxiety disorder, excessive fear, worry and physical tension are to the fore — drive tends to be preserved or even increased (restlessness). In depression, loss of pleasure and drive and a low underlying mood dominate. Because the two can occur together, the precise classification is the task of the professional — and it influences which therapy and which medication make sense.

  • A detailed consultation about the complaints, duration, course and burdens.
  • Standardised questionnaires (e.g. the PHQ-9) help to assess severity and course.
  • A physical examination and blood values to rule out other causes.
  • Asking about suicidal thoughts — this is always part of it and is a sign of care, not of mistrust.

6. Treatment by severity

How a depression is treated depends above all on its severity. There is no single right therapy for everyone — mild episodes often need something different from severe ones. The three building blocks are psychotherapy, antidepressants and supporting measures; they can be used individually or in combination.¹

Mild Active monitoring & low-threshold help
Watchful waiting
For a mild episode, the guidelines often first recommend active monitoring over about two weeks, frequently with a follow-up appointment. Many mild episodes improve on their own. Antidepressants are usually not the first choice here.
Self-help & exercise
Guided self-help, physical activity and online programmes can demonstrably help with mild episodes and lower the risk of relapse.
Moderate Psychotherapy or an antidepressant
Psychotherapy
For moderate episodes, psychotherapy and antidepressants are in principle equally effective. The best-evidenced approach is cognitive behavioural therapy. Which path fits is something you decide together with your treating professional — your own preference counts too.
Antidepressant
A medication is an equivalent alternative, especially when no psychotherapy is available at short notice or you prefer it. Details on the drug groups in the next section.
Severe A combination of both
Combination therapy
For a severe episode, the combination of psychotherapy and an antidepressant is recommended — together they work better than either building block alone. In very severe cases or with acute risk to oneself, treatment in a hospital may be necessary.

7. Antidepressants in plain terms

Antidepressants are not addictive and do not change your personality. They act on the balance of neurotransmitters in the brain and help to bring mood, drive and sleep back into balance. Which drug fits depends on the complaints, coexisting illnesses and tolerability. Here are the most important groups in plain terms:¹

First line The mainstay drug groups
Selective serotonin reuptake inhibitors are usually the first choice today. They are well studied and relatively well tolerated. Typical side effects at the start: nausea, restlessness and sexual dysfunction — much of this improves after the first few weeks.
SNRIs (e.g. Venlafaxine)
Serotonin-noradrenaline reuptake inhibitors act on two neurotransmitters. They are often used when an SSRI is not enough, and can also help with accompanying pain. Note: a possible rise in blood pressure and pulse.
Works through a different mechanism and tends to make you drowsy — which is why it is often helpful with pronounced sleep disturbances and loss of appetite. It is usually taken in the evening. Typical: increased appetite and weight gain.
Tricyclic antidepressants (e.g. Amitriptyline)
An older, effective group. However, they have more side effects (dry mouth, constipation, drop in blood pressure, strain on the heart) and are more dangerous in overdose. That is why they are no longer the first choice today, but remain sensible for certain courses of illness.
Patience in the first few weeks Antidepressants do not work immediately. It usually takes two to six weeks before the mood-lifting effect sets in — at the start, side effects can even appear before the improvement becomes noticeable. This is not a sign that the medication is not working. Important: in this initial phase, drive can return before the mood lifts — which is why close support is so important, especially at the beginning. Do not stop the medication on your own because "nothing is happening".

Another honest point concerns stopping. If an antidepressant is reduced too quickly or stopped abruptly, discontinuation symptoms can occur: dizziness, a flu-like feeling, "electric shock" sensations in the head, restlessness, sleep problems. This is not dependence but the body's readjustment reaction — it can almost always be avoided by slowly tapering the dose over weeks. How to do this in practice is explained in the guide Stopping SSRIs correctly.

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  • Intake reminder for every dose
  • Mood and side-effect history
  • Interactions checked
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8. Course, stopping & everyday life

Depression is as a rule time-limited: an untreated episode often lasts several months, with treatment it is usually quicker. Once the symptoms have subsided, an antidepressant is not stopped straight away but continued for several more months (maintenance therapy) to prevent a relapse. With repeated episodes, longer-term preventive use can be sensible.¹

  • Tablets at a fixed time: a fixed routine increases reliability. If you forget a dose, do not simply take a double dose.
  • Do not stop on your own: even if you feel better — always coordinate stopping with your practice and taper slowly.
  • Structure and exercise: a regular daily routine, small achievable goals and regular exercise have a demonstrably mood-lifting effect.
  • Keep in touch: even when withdrawal is tempting — social contacts are a protective factor.
  • Avoid alcohol: it worsens depressive symptoms and can interact unfavourably with medication.
Relapses are not a failure The fact that episodes can recur is part of the nature of the illness — it says nothing about your willpower. Those who know their own early warning signs (e.g. sleep problems, withdrawal, rumination) and take countermeasures early can often take the force out of a relapse.

Keep an eye on your early warning signs

Record in brite how your mood, sleep and drive develop — this way you spot changes early and have everything ready for your next appointment.

Document the course

9. When thoughts of dying arise

Thoughts of death or of no longer wanting to live are a common symptom of depression — and a reason to actively seek help. Such thoughts do not mean that you are "crazy" or that there is no way out. They are an expression of the illness, and the illness is treatable.

Acute suicidal thoughts — get help now If you have concrete thoughts of taking your own life, do not wait: dial the emergency number 112 or go to the nearest emergency department. Around the clock, free of charge and anonymously, you can reach the Telefonseelsorge on 0800 111 0 111 or 0800 111 0 222. The medical on-call service on 116 117 can also help. You do not have to get through this alone — seeking help is a sign of strength.

If you are worried about another person: speak openly about what you have noticed. Asking about suicidal thoughts does not put "the wrong ideas" into anyone's head — on the contrary, it relieves them and opens the door to help. Always take such statements seriously and encourage professional support.


How brite helps you with depression

Depression is not treated in days but over months — and especially at the start, when the medication is not yet working, it takes patience and structure. That is exactly where brite supports you.

  • Intake reminder — take your SSRI, SNRI or Mirtazapine reliably and without gaps, especially in the first few weeks. Set up a reminder
  • Health history — document your mood, sleep and side effects and bring them along as a history to your appointment. Ideal for assessing when the effect sets in. Track your history
  • Interaction check — spots critical combinations, such as several serotonergic drugs or antidepressants plus certain painkillers. Check now
  • Digital medication plan — all your preparations clearly laid out for your GP, psychiatry and pharmacy. To the medication plan
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FAQ: Common questions about depression

Depression is present when low mood, loss of interest and lack of drive persist almost daily for at least two weeks and impair everyday life. A normal passing low usually resolves on its own and can be lifted by pleasant moments — a depression cannot. With persistent symptoms, a medical assessment is worthwhile.
The mood-lifting effect usually only sets in after two to six weeks. In the first few days, side effects can even appear before any improvement is noticeable. This is not a sign that the medication is not working. It is important not to stop it on your own and to discuss the course with your practice.
No. Antidepressants are not addictive and do not change your personality. However, if a preparation is stopped too quickly, temporary discontinuation symptoms such as dizziness, restlessness or "electric shock" sensations can occur. This is not an addiction but a readjustment reaction — it can almost always be avoided by slowly tapering over weeks.
"Burnout" is not a diagnosis in its own right but a state of exhaustion strongly tied to work and overload. A depression is a clearly defined illness that affects all areas of life and whose core is the loss of pleasure and drive. A persistent state of exhaustion can develop into a depression — which is why a professional assessment is sensible.
In an anxiety disorder, excessive fear, worry and physical tension are to the fore, while drive tends to be preserved or increased as restlessness. In depression, loss of pleasure and drive and a low underlying mood dominate. The two often occur together, which is why precise classification by a professional is important — it influences the choice of therapy.
That depends on the severity. With mild episodes, monitoring and low-threshold help often come first. With moderate episodes, psychotherapy and antidepressants are equivalent — your preference counts too. With severe episodes, the combination of both is recommended. You make the decision together with your treating professional.
Not on your own. Once the symptoms have subsided, the medication is usually continued for several more months to prevent a relapse (maintenance therapy). Stopping then happens slowly and in agreement with your practice, to avoid discontinuation symptoms. Ending it too early or abruptly increases the risk of relapse.
Yes. Regular physical activity has a demonstrably mood-lifting effect and can help especially with mild and moderate episodes as well as prevent relapses. With more severe courses it does not replace psychotherapy or medication, but it is a valuable building block. Even regular walks and a regular daily routine make a difference.
Get help immediately. If you have concrete thoughts of taking your own life, dial the emergency number 112 or go to the nearest emergency department. Around the clock, free of charge and anonymously, you can reach the Telefonseelsorge on 0800 111 0 111 or 0800 111 0 222. Such thoughts are a symptom of the illness, and the illness is treatable — you do not have to get through this alone.

11. Related topics

Sources

  1. National Care Guideline (NVL) Unipolar Depression, 3rd edition (2022). BÄK, KBV, AWMF. leitlinien.de
  2. gesundheitsinformation.de (IQWiG): Depression. gesundheitsinformation.de
  3. Deutsche Depressionshilfe (Stiftung Deutsche Depressionshilfe). deutsche-depressionshilfe.de
  4. Telefonseelsorge Deutschland. telefonseelsorge.de
Medical disclaimer: This article is for general information and does not replace medical or psychotherapeutic advice, diagnosis or treatment. Antidepressants should never be stopped or have their dose changed on your own — if you have questions, contact your treating practice. If you have acute thoughts of taking your own life, immediately dial the emergency number 112 or the Telefonseelsorge on 0800 111 0 111 or 0800 111 0 222. Last updated: July 2026.