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Acute respiratory infections are among the most common illnesses of all – many adults have several a year. They are mostly caused by viruses and affect the upper airways (nose, throat, larynx) and/or the lower airways (bronchi, lungs).¹
The four most important viral respiratory infections are: the common cold, flu (influenza), COVID-19 and RSV. All are transmitted mainly by droplets or aerosols and occur more often in the autumn and winter months.¹
Important: symptoms alone are not enough for a diagnosis
A reliable distinction between cold, flu, COVID-19 and RSV is usually NOT possible from the symptoms alone – often only a lab test (swab/PCR/rapid test) provides clarity.
Colds can be triggered by a wide variety of pathogens – often rhinoviruses, alongside seasonal coronaviruses (not SARS-CoV-2), adenoviruses and parainfluenza viruses. They are usually mild and typically clear up on their own within about a week.⁵
Duration and possible complications
The main symptoms usually subside within a week. In risk groups (immunocompromised, small children, seniors), complications can occasionally occur (e.g. bronchitis, sinusitis, middle-ear infection in children).
True flu is caused by influenza viruses and often runs a markedly more severe course than a cold. Depending on the severity of the wave, the RKI estimates between close to zero (mild season) and well over 20,000 additional deaths (very severe seasons such as 2017/18).¹ Older and chronically ill people are usually especially at risk.
Possible complications
Pneumonia, inflammation of the heart muscle (myocarditis) or worsening of chronic conditions such as asthma, COPD, diabetes or heart disease.¹
Risk groups (per STIKO)
People aged 60 and over, people with chronic underlying conditions (airways, heart, kidney, metabolism), the immunocompromised, residents of care facilities and healthcare staff.²
Antiviral therapy for flu (oseltamivir)
For certain risk groups, antiviral therapy can be considered within about the first 48 hours after symptom onset. Prescription-only – the decision is always made by the treating doctor.
COVID-19 is caused by the virus SARS-CoV-2. After the pandemic, SARS-CoV-2 has become one of the seasonally circulating respiratory viruses. Thanks to the now widespread immunity (vaccinations and past infections), most infections today run a rather mild course.³
Long COVID: long-term effects after COVID-19
Long COVID or post-COVID refers to long-term effects that can persist for weeks to months after the acute infection: e.g. persistent exhaustion (fatigue), concentration problems (“brain fog”), shortness of breath, sleep problems or a racing heart. Long COVID can in principle affect any age group – even after mild courses. According to current data, vaccination and early antiviral therapy appear to lower the risk.
Antiviral therapy for COVID-19 (Paxlovid)
For certain risk groups, nirmatrelvir/ritonavir (Paxlovid) is available – within a few days of symptom onset. Prescription-only. Important: Paxlovid has numerous interactions – a medical and pharmacy review is always required before use. More: drug interactions.³
RSV is often underestimated but is considered one of the most common causes of hospital admissions in infants and can also lead to severe courses in seniors (e.g. pneumonia, worsening of existing COPD or heart failure).⁶
Protective measures against RSV (expanded since 2024)
Nirsevimab (Beyfortus) – passive immunisation, recommended by the STIKO for all infants in their first RSV season.⁶ RSV vaccination for older people – recommended by the STIKO as a standard vaccination from a certain age and as an indication-based vaccination with relevant pre-existing conditions.⁶
In detail: RSV article.
For rough orientation only – not a diagnosis
A reliable distinction is usually only possible by lab test. Practices increasingly have multiplex tests that can detect influenza, SARS-CoV-2 and RSV from a single swab.¹
| Feature | Cold | Flu | COVID-19 |
|---|---|---|---|
| Onset | Gradual (1–2 days) | Often sudden (hours) | Variable (1–3 days) |
| Fever | Rather rare, low | Often high | Common, variable |
| Runny nose | Dominant – leading symptom | Less prominent | Common with current variants |
| Body aches | Usually mild | Often severe – typical | Occur commonly |
| Feeling of illness | Rather mild | Usually severe, bed rest needed | Variable |
| Loss of smell | Only with congestion | Rare | Possible (rarer now) |
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Call 112 immediately for:
Shortness of breath at rest, chest pain when breathing, clouded consciousness or confusion, bluish lips or fingernails (cyanosis), a febrile seizure in children, pauses in breathing or persistent refusal to drink in infants.
Most respiratory infections clear up on their own. Treatment usually aims to relieve the symptoms.
Paracetamol or ibuprofen can be used for fever, headache and body aches. Important: in children and adolescents under 16, acetylsalicylic acid (ASA) is usually not recommended because of the rare but dangerous Reye’s syndrome. More: medication before or after eating.
Saline solution (e.g. as a nasal spray or nasal rinse) is usually well tolerated. Decongestant nasal sprays (e.g. with xylometazoline) should only be used for a limited time to avoid a rebound effect (rhinitis medicamentosa).
Lozenges, warm or cool drinks, gargling with salt water or sage tea can help.
Inhalations with saline solution moisten the mucous membranes. Herbal expectorants (e.g. with thyme or ivy) are often used. Honey can be used as a home remedy for children from one year – for infants under one year, honey is off-limits because of the botulism risk.
Antibiotics do NOT help against viral respiratory infections
Cold, flu, COVID-19 and RSV are viral infections – antibiotics only work against bacteria. They are prescribed in a targeted way only for bacterial complications (e.g. bacterial pneumonia, middle-ear infection). Unnecessary use can promote resistance. More: taking antibiotics correctly.
| Illness | Active substance | Notes |
|---|---|---|
| Flu | Oseltamivir (e.g. Tamiflu) | Usually within the first ~48 hours after symptom onset. Prescription-only. Only for risk groups. |
| COVID-19 | Nirmatrelvir/ritonavir (Paxlovid) | Numerous interactions – medical and pharmacy review essential. Prescription-only. Only for risk groups. |
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The STIKO recommends an annual flu vaccination – usually in autumn (about October–November). Recommended, among others, for:²
The STIKO recommends an annual booster in autumn, mainly for:³
For healthy adults under 60, the STIKO generally considers the basic immunity sufficient.³
Several vaccinations on the same day possible
According to the STIKO, flu, COVID-19 and pneumococcal vaccines can usually be given on the same day (then in different arms). Which vaccinations make sense in the individual case is decided by the treating doctor.²˒³
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