Type 2 Diabetes:
Symptoms, Medications & What You Can Do Yourself

At a glance

Affected in Germany ~10.3% of adults with diagnosed diabetes; plus an estimated number of undiagnosed cases
Share Over 90% of all diabetes cases
Cause Generally insulin resistance + relative insulin deficiency; interplay of genetics and lifestyle factors
Remission Possible in individual cases — especially in the first years through weight loss and lifestyle change
Medications (selection) Metformin, SGLT2 inhibitors (e.g. empagliflozin), GLP-1 RAs (e.g. semaglutide, tirzepatide), insulin if needed
ICD-10 E11

1. What is Type 2 diabetes?

Type 2 diabetes is a chronic metabolic condition in which two problems generally come together: the body's cells no longer respond adequately to insulin (insulin resistance) and the pancreas can over time usually no longer fully compensate for the rising demand (relative insulin deficiency). Blood glucose remains persistently elevated and can gradually damage blood vessels, nerves and organs.

In Germany, the prevalence of diagnosed diabetes was around 10.3% of adults according to the Robert Koch Institute (2024 panel analysis).³ Type 2 accounts for by far the largest share of all diabetes cases.

Remission is possible Type 2 is currently the only form of diabetes for which remission has been described. Particularly in the first years after diagnosis, weight loss, dietary change and regular exercise can in some cases normalize blood glucose to the point that no medications are temporarily needed.¹

2. Symptoms — often unnoticed for years

The tricky part about Type 2: the condition generally develops gradually over months to years. Many people have no or only nonspecific symptoms for a long time — and the diabetes is often only detected at routine check-ups or in the context of complications.

  • Increased thirst and frequent urination — sometimes also at night
  • Fatigue and drop in performance without a clear cause
  • Increased susceptibility to infections — particularly urinary tract infections and fungal infections
  • Poorly healing wounds
  • Vision problems — e.g. temporarily blurred vision due to changes in the lens of the eye
  • Tingling or numbness in hands and feet (possible signs of polyneuropathy)
  • Itching, dry skin
  • Dark patches of skin in body folds (acanthosis nigricans — can indicate insulin resistance)
Get tested early — even without symptoms A not-small proportion of people in Germany live with undiagnosed diabetes.³ From around your mid-30s onwards, have your blood glucose checked at your health check-up — a simple blood test is generally enough.

3. Prediabetes: recognize the precursor and act

Prediabetes is a precursor stage of Type 2 diabetes: blood glucose is already elevated but not yet in the diabetes range. Without countermeasures, in many cases manifest diabetes develops over time.¹

Approximate values for prediabetes Fasting blood glucose 100–125 mg/dL (5.6–6.9 mmol/L) OR HbA1c 5.7–6.4% OR a 2-hour OGTT value between 140 and 199 mg/dL.
At this stage, a lot can still be done Studies of lifestyle intervention in prediabetes have shown that a combination of balanced nutrition, regular exercise and moderate weight loss can significantly reduce the risk — in some studies the effect was even greater than with medications.¹

Warning signs of elevated risk: increased waist circumference (> 80 cm in women, > 94 cm in men, per IDF cutoffs for Europids), family history of diabetes, dark skin patches (acanthosis nigricans) or previous gestational diabetes.


4. Causes and risk factors

Main risk factors

  • Overweight/obesity — considered the most important modifiable factor. Visceral abdominal fat in particular increases the risk
  • Lack of exercise — can directly promote insulin resistance, independently of weight
  • Genetic predisposition — diabetes in first-degree relatives can increase the risk
  • Age — risk rises from middle age onwards; however, younger adults are increasingly affected
  • Socioeconomic factors — people in groups with lower socioeconomic status are significantly more often affected³

Other risk factors

  • Previous gestational diabetes
  • PCOS (polycystic ovary syndrome)
  • Chronic sleep deprivation and sleep apnea
  • Certain medications (e.g. prolonged cortisone therapy, certain antipsychotics)
  • Smoking — increases the risk of Type 2 in studies
  • Unfavorable dietary patterns (high sugar, many ultra-processed foods)

5. Diagnosis

The diagnosis is generally made using defined lab values. For a reliable diagnosis, the current guideline usually requires two pathological lab values.¹

  • Fasting blood glucose ≥ 126 mg/dL (7.0 mmol/L) — generally confirmed on two different days
  • HbA1c ≥ 6.5% (48 mmol/mol) — the "long-term blood glucose" of the past 2–3 months
  • 2-hour OGTT value ≥ 200 mg/dL (11.1 mmol/L)
  • Random blood glucose ≥ 200 mg/dL with typical symptoms at the same time
Extended baseline screening after a new diagnosis Blood pressure, lipids (cholesterol, triglycerides), kidney values (eGFR, urinary albumin), liver values, ophthalmologic examination, foot status.

Learn more: Preparing for a doctor's appointment.


6. Treatment without medications — the foundation

Lifestyle therapy is the cornerstone of every Type 2 diabetes treatment. In the first years after diagnosis, it can in individual cases even lead to remission.¹

Nutrition

  • A special "diabetic diet" is generally not necessary — a balanced, wholesome diet is usually enough
  • The Mediterranean diet has good evidence in studies: plenty of vegetables, fruit, legumes, whole grains, olive oil, fish; little red meat and little sugar
  • Consistently reduce sugar and sugary drinks — usually the biggest single lever
  • Reduce ultra-processed foods where possible
  • Eat plenty of fiber — fiber generally slows sugar absorption
  • Intermittent fasting (e.g. 16:8) can be an effective strategy

Exercise

  • Generally recommended: around 150–300 minutes of moderate activity per week (e.g. brisk walking, swimming, cycling)
  • Combination of endurance and strength training — building muscle can improve insulin sensitivity
  • Regularly interrupt sitting time
  • Every bit of movement counts — even short sessions are generally better than none
Use the DMP Diabetes program People with Type 2 diabetes in Germany are generally entitled to participate in the Disease Management Program (DMP) Diabetes — a German structured care program. It includes structured education, regular check-ups and nutritional counseling. Enrollment is usually via your GP.

7. Medications: stepped therapy per NVL

When lifestyle measures are not enough, medications are added. The selection is generally based on comorbidities and individual risk profile.¹˒²

Core principle of the 2024 NVL In existing cardiovascular or kidney disease, SGLT2 inhibitors or GLP-1 receptor agonists are generally used early — not only after a metformin trial.¹
Step 1 Metformin — the standard drug

Metformin has been the first-choice standard therapy for decades. Among other things, it suppresses glucose production in the liver and improves insulin sensitivity. Unlike insulin or sulfonylureas, it generally does not cause hypoglycemia, is usually weight-neutral and well studied.¹

Metformin (e.g. Glucophage, various generics)
Use: Generally titrated up gradually and taken with food — to reduce gastrointestinal complaints
Side effects: Nausea, diarrhea, bloating (improve for many people after a few weeks). Extended-release form often better tolerated
Contraindication: Severely impaired kidney function — regular kidney monitoring required
Learn more: Medication before or after eating
Step 2 Combination — often early in heart or kidney disease
SGLT2 inhibitors (gliflozins) — heart and kidney protection
Examples: Empagliflozin (Jardiance), dapagliflozin (Forxiga in EU / Farxiga in US)
Mechanism: Glucose is excreted in greater amounts via the urine
Added benefit: Large trials (EMPA-REG, DAPA-CKD) have shown favorable effects on heart failure and kidney function. The guideline recommends early use in relevant heart or kidney disease.¹
Side effects: Genital fungal infections and urinary tract infections. Rarer: euglycemic ketoacidosis (possible even at normal blood glucose levels — seek medical advice)
GLP-1 receptor agonists — blood glucose, weight and heart protection
Examples: Semaglutide (Ozempic as an injection, Rybelsus as a tablet), dulaglutide (Trulicity), liraglutide (Victoza), tirzepatide (Mounjaro — a dual GLP-1/GIP agonist)
Mechanism: Mimic the gut hormone GLP-1 — can boost insulin secretion, slow gastric emptying and act on the satiety center
Added benefit: Cardiovascular benefit shown for several substances in certain patient groups (among others, semaglutide and tirzepatide)
Side effects: Nausea, vomiting, constipation at the start — stepwise dose escalation generally helps
In development: Orforglipron (an oral GLP-1 tablet without a fasting requirement), CagriSema (semaglutide + an amylin analogue)
DPP-4 inhibitors (gliptins)
Examples: Sitagliptin (Januvia), linagliptin (Trajenta in EU / Tradjenta in US)
Well tolerated and generally do not cause hypoglycemia. Blood glucose lowering on average weaker than with SGLT2 inhibitors or GLP-1 RAs. No additional cardiovascular benefit shown in trials.
Sulfonylureas
Examples: Glibenclamide (known as glyburide in the US), glimepiride
Lower blood glucose reliably but carry a risk of hypoglycemia and can contribute to weight gain. Used less often today than in the past — generally only in specific situations.¹
Step 3 Triple combination or insulin

When a two-drug combination is not enough, a further step may be sensible — e.g. the combination of metformin, an SGLT2 inhibitor and a GLP-1 receptor agonist, or the addition of a basal insulin. The use of insulin in Type 2 is generally not a "failure" of therapy but reflects the natural course of the disease.¹

Do not stop medications on your own Diabetes medications should generally not be stopped on your own or have their dose changed unilaterally — blood glucose can otherwise spiral out of control. Always discuss changes with your diabetes team. Learn more: Stopping medication, Check interactions.

8. Complications and sequelae

Acute complications

Hypoglycemia — act immediately Typical warning signs: trembling, sweating, palpitations, ravenous hunger, problems with concentration or confusion. Immediate measure: take fast-acting carbohydrates. Important: hypoglycemic episodes occur mainly with insulin and sulfonylureas — with metformin, SGLT2 inhibitors or GLP-1 RAs alone, they are significantly rarer.
Hyperosmolar hyperglycemic state — call 112 immediately! Very high blood glucose, severe dehydration, progressive impairment of consciousness — a medical emergency.

Chronic complications

Many of the possible complications can be delayed or prevented through good metabolic control, regular check-ups and the treatment of other risk factors:

  • Eyes (diabetic retinopathy) — one of the common causes of severe vision loss; annual ophthalmologist check-ups important
  • Kidneys (diabetic nephropathy) — regular monitoring of kidney values and urinary albumin
  • Nerves (diabetic neuropathy) — tingling, numbness, diabetic foot syndrome
  • Cardiovascular — significantly increased risk of heart attack and stroke; cardiovascular disease is among the most common causes of death in Type 2
  • Fatty liver disease (MASLD)
  • Erectile dysfunction
  • Depression — more common in people with diabetes than in the general population

9. Screening check-ups

  • Quarterly: HbA1c, blood pressure, inspection of the feet, where applicable a discussion of self-monitoring of blood glucose
  • Annually: Eye examination, kidney values (eGFR + urinary albumin), lipids, structured foot examination, cardiovascular assessment
  • Also regularly: Checks for neuropathy and peripheral artery disease (PAD)
  • Dental check-ups — periodontitis can occur more often in people with diabetes

10. Living with Type 2 diabetes

  • Blood glucose monitoring: How often to measure depends on the therapy. On metformin alone, daily self-monitoring is usually not necessary. On insulin or sulfonylureas, it's generally done regularly.
  • Alcohol: Alcohol can increase the risk of hypoglycemia in combination with insulin or sulfonylureas — generally not on an empty stomach. Learn more: Medication and alcohol.
  • Travel: Take medications in sufficient quantities (usually double), transport insulin cool (do not freeze), and carry a doctor's certificate for syringes and pen in your hand luggage. Learn more: Medication when traveling.
  • Vaccinations: Germany's Standing Committee on Vaccination (STIKO) generally recommends an annual flu vaccination for people with diabetes, as well as — depending on the individual situation — COVID-19 and pneumococcal vaccinations.
  • Driver's license: Type 2 diabetes is generally not a fundamental obstacle. On insulin or sulfonylurea therapy, a blood glucose check before driving is often advisable.

How brite helps you with Type 2 diabetes

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FAQ: Common questions about Type 2 diabetes

Not in the classical sense, but remission is possible in individual cases: through consistent weight loss, dietary change and exercise, some people can temporarily go without medications. The earlier this is started, the better the chances often are. With significant obesity, remissions have also been described after bariatric surgery. There is a risk of relapse — so regular check-ups remain important.¹
In most cases not right away — many people with Type 2 manage initially with tablets and/or GLP-1 receptor agonists. Insulin is generally only added when other options are no longer sufficient or when the body's own insulin production drops significantly. The transition to insulin is usually not a "treatment failure."
Both are GLP-1 receptor agonists. Ozempic contains the active ingredient semaglutide, Mounjaro contains tirzepatide. They can lower blood glucose, affect appetite and lead to weight loss in some patients. Cardiovascular benefit in certain patient groups has been shown in trials for several substances in this class.
Prediabetes refers to a precursor stage of Type 2 diabetes: blood glucose is elevated but not yet in the diabetes range (e.g. fasting glucose 100–125 mg/dL or HbA1c 5.7–6.4%). Without countermeasures, diabetes often develops over time. Structured lifestyle change can significantly reduce the risk of progression.¹
Below 5.7% is generally considered normal, 5.7–6.4% is prediabetes, from 6.5% is diabetes. The individual treatment target under therapy is often below 7.0% — but can be set higher depending on age, comorbidities and risk of hypoglycemia. The target is always determined individually with your doctor.¹
Persistently elevated blood glucose can lead to damage to the eyes, kidneys, nerves and blood vessels over the years. Possible consequences include significant vision loss, decline in kidney function up to needing dialysis, foot problems and a significantly increased risk of heart attack or stroke.
With a diagnosis of Type 2 diabetes, Ozempic and Mounjaro are generally covered by statutory health insurance in Germany. For obesity without diabetes, the situation is usually different — there they are currently classified as so-called lifestyle medications. When in doubt, check with your own insurer.
Gastrointestinal complaints with metformin are common in the first weeks and improve over time for many people. A gradual dose escalation and taking it with food are usually helpful. An extended-release form is often better tolerated. If the complaints persist, the approach should be discussed with your doctor — do not stop on your own.

13. Related topics

Sources

  1. National Disease Management Guideline on Type 2 Diabetes, Version 3 (ÄZQ/AWMF, December 2024). awmf.org
  2. NVL Type 2 Diabetes — Chapter on Pharmacological Therapy. leitlinien.de
  3. Robert Koch Institute: Diabetes mellitus — Prevalence in Adults (panel analysis 2024). gbe.rki.de
  4. Robert Koch Institute: National Diabetes Surveillance — Results 2015–2024. diabsurv.rki.de
  5. German Diabetes Association (DDG): Diabetes Health Report and Factsheet. ddg.info
  6. Publications on cardiovascular effects of semaglutide and tirzepatide (Nature Medicine, 2025). nature.com
  7. diabinfo.de — Medications for Type 2 Diabetes. diabinfo.de
  8. gesundheitsinformation.de (IQWiG): Type 2 Diabetes. gesundheitsinformation.de
Medical disclaimer: This article is for general information only and is not a substitute for medical advice, diagnosis or treatment. Dosages, choice of medication and treatment goals (e.g. an individual HbA1c target) are always determined individually by your treating diabetes team. In case of loss of consciousness or extremely high blood glucose, call emergency services (112 in the EU/UK) immediately. Diabetes medications should generally not be stopped on your own. Last updated: April 2026.