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Relaxed in the morning, irritable at midday, sad for no reason in the evening: almost everyone knows mood swings. To a certain degree they are part of life. They become a burden when they occur frequently, intensely or without a recognisable trigger and affect relationships, work or sleep. Behind pronounced swings there is often a treatable cause – the thyroid, the cycle or the menopause, but sometimes also depression or bipolar disorder. Here you learn when mood swings are normal, when they should be investigated medically – and where to get immediate help in a crisis.
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With suicidal thoughts or an acute crisis, get help immediately: Telefonseelsorge (German crisis line) 0800 111 0 111 or 0800 111 0 222 – free, around the clock. In the US: call or text 988 (Suicide & Crisis Lifeline).
Mood swings describe a frequent, often rapid change in emotional state. Within hours or days, the mood switches between positive feelings like joy and balance and negative feelings like irritability, sadness, anger or inner restlessness. To a certain degree, such changes are completely normal and part of human experience.
Mood swings become problematic when they occur frequently, intensely or without a recognisable trigger and noticeably affect life – relationships, work, sleep or one's own wellbeing. Then there is often a medical, hormonal or psychological cause behind it that should be investigated.
Thyroid: an overactive thyroid causes irritability, inner restlessness and nervousness, an underactive one rather a low mood and a lack of drive. Both can be treated well – a TSH value clarifies it quickly.
Cycle and PMS: 3–8 days before menstruation, many women report low moods, irritability or anxiousness. With strongly pronounced symptoms it is called premenstrual dysphoric disorder (PMDD) – treatable.
Menopause: the drop in oestrogen can trigger mood swings, sleep problems and depressive moods. Hot flushes and night-time lack of sleep intensify the symptoms.
Pregnancy and the postnatal period: hormonal changes alter the mood in both directions. Postnatal depression should be recognised and treated in time.
In men – testosterone: a testosterone deficiency in middle to older age can show itself as irritability, a lack of drive and mood swings – in men often hidden behind "tiredness" or "stress".
Overactive thyroid and underactive thyroid, premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD), menopause, pregnancy and the postnatal period, testosterone deficiency.
Depression: a low mood over a longer period, a lack of drive, loss of interest, sleep problems, self-reproach.
Bipolar disorder: a change between depressive and manic/hypomanic phases (elevated drive, reduced need for sleep, increased activity, risky behaviour).
Cyclothymia: a persistently unstable mood with numerous mild depressive and hypomanic phases.
Borderline personality disorder: rapid, intense mood changes, often as a reaction to relationship events.
Anxiety disorders and adjustment disorders: can be accompanied by pronounced mood swings.
Lack of sleep, stress, being over- or under-challenged, lonely phases of life, acute strains (separation, bereavement, job loss), vitamin D deficiency in winter, substance use (alcohol, cannabis, drugs).
Cortisone, beta blockers, thyroid preparations, hormonal contraception, antidepressants (especially at the start), sleeping pills, some painkillers.
Vitamin D or B12 deficiency, chronic illnesses (diabetes, heart failure), neurological illnesses (Parkinson's, multiple sclerosis, dementia), chronic pain.
Mood changes are not automatically abnormal – everyone has them. The transition from "normal" to "needs investigation" shows itself in a few features:
| Feature | Normal swings | Abnormal swings |
|---|---|---|
| Trigger | Recognisable (stress, sleep, conflict) | Often without a recognisable trigger |
| Intensity | Proportionate to the situation | Disproportionate or overwhelming |
| Duration | Hours to a few days | Weeks to months |
| Everyday life | Remains functional | Work, relationships, sleep are affected |
| Accompanying symptoms | None | Sleep problems, loss of energy, suicidal thoughts, physical symptoms |
Also important: in adolescents, mood swings during puberty are largely normal – hormonal change, finding an identity, social pressure and shifts in sleep come together. Attention is warranted, however, when persistent dejection, social withdrawal, a drop in school performance, self-harm or suicidal thoughts are added. Point of contact: the paediatric practice, school psychology services or the Nummer gegen Kummer (German youth helpline): 116 111.
Overactive thyroid → antithyroid drugs; underactive thyroid → levothyroxine. For PMS/PMDD: lifestyle adjustment, if needed an SSRI in the luteal phase, in some cases hormonal contraception. For menopausal symptoms: hormone replacement therapy after an individual assessment. For testosterone deficiency in men: substitution after a confirmed diagnosis.
Psychotherapy (cognitive behavioural therapy, psychodynamic therapy) is the first-line therapy for depression, anxiety disorder and personality disorders. For moderate to severe episodes, a combination with drug therapy (SSRIs, SNRIs, mood stabilizers for bipolar disorder such as lithium, valproate, lamotrigine). Important: the diagnosis of bipolar disorder must be clarified before antidepressant therapy – antidepressants without a mood stabilizer can trigger manic phases in bipolar patients.
A regular sleep-wake rhythm, exercise in the fresh air, a balanced diet, maintaining social contacts, reducing alcohol and caffeine. A mood diary via apps or notebooks helps to recognise triggers and to document treatment success. With mild low moods, St John's wort, lavender, passionflower or valerian can have a supporting effect – caution: St John's wort has numerous interactions (e.g. with the pill and blood thinners), get medical advice before taking it.
Some medications can change the mood – others are the most important treatment option. An overview:
| Medication | Effect on mood |
|---|---|
| Cortisone (systemic) | Can trigger irritability, sleep problems, euphoria or depressive moods – especially at higher doses |
| Hormonal contraception | Can intensify low moods in some women – a change of preparation can help |
| SSRIs / SNRIs (antidepressants) | First-line therapy for depression – the effect sets in after 2–6 weeks, possibly restlessness at first |
| Mood stabilizers (lithium, valproate, lamotrigine) | Core therapy for bipolar disorder – regular blood level checks necessary |
Also beta blockers, thyroid preparations (with over- or under-dosing), sleeping pills and some painkillers can influence mood. If mood swings coincide in time with a new medication, this should be discussed medically.
Digital medication plan: record all preparations – your GP, psychiatry, endocrinology and gynaecology see immediately which active ingredients can influence the mood. → Create a medication plan
Interaction check: which medications can change the mood? → Start the interaction check
Intake reminder: take antidepressants, mood stabilizers and thyroid medications regularly. → Set up a reminder
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