Sleep Problems:
Causes, Medications & What Really Helps

You lie awake, tossing and turning, and the next morning you feel exhausted. Sleep problems — whether difficulty falling asleep, staying asleep, or waking too early — are among the most common health complaints. What many people don't realise: certain medications can significantly disrupt your sleep. From beta-blockers to thyroid hormones to cortisone — it is worth taking a close look at your medication.

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1. What You Can Do Right Now

Quick relief for sleep problems

  • Routine: Go to bed and get up at the same time every day — including weekends.
  • Screens: Put away your smartphone, tablet, and laptop 60 minutes before bed.
  • Temperature: Cool the bedroom to 61–64 °F (16–18 °C) and keep it dark.
  • Caffeine: No coffee, tea, or cola after 2 PM.
  • Review your medications: Are you taking beta-blockers, levothyroxine, prednisolone, or antidepressants? These can disrupt sleep.
Crisis support: Samaritans 116 123 For days of insomnia with severe exhaustion, confusion, or suicidal thoughts: please seek help immediately. Samaritans: 116 123 (free, around the clock).

2. Understanding Sleep Problems — When Is It More Than Just a Bad Night?

Sleep problems (medically: insomnia) become clinically significant when you sleep poorly at least three times per week — over a period of more than four weeks.

TypeDescription
Difficulty falling asleepYou lie awake for more than 30 minutes before falling asleep
Difficulty staying asleepYou wake in the night and cannot get back to sleep
Early wakingYou wake much too early and still feel tired — typical with depression
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The consequences show up during the day: fatigue, difficulty concentrating, irritability, and reduced performance.

3. Common Causes of Sleep Problems

3.1 Medications — a frequently overlooked factor

MedicationWhy it disrupts sleepSolution
Bisoprolol, metoprolol (beta-blockers)Suppress melatonin production → vivid dreams, difficulty staying asleepSpeak to your doctor; melatonin supplement may help
LevothyroxineWhen overdosed: heart palpitations, restlessness, insomniaCheck TSH, adjust dose
Prednisolone (cortisone)Activates the metabolism — especially if taken in the eveningAlways take in the morning!
Citalopram, escitalopram (SSRIs)Sleep disturbances possible particularly in the first few weeksUsually resolves after 2–4 weeks
Torasemide (diuretic)Night-time trips to the toilet when taken in the eveningAlways take in the morning!
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3.2 Stress and psychological burden

Rumination, worry, and work pressure — psychological stress is the most common cause of difficulty falling asleep. Early waking (4–5 AM) is typical of depression.

3.3 Sleep apnoea and snoring

Breathing pauses during sleep cause unconscious waking and unrefreshing sleep. Typical signs: loud snoring, extreme daytime sleepiness, a partner reporting breathing pauses. Particularly affects people who are overweight.

3.4 Pain and other symptoms

Chronic back pain, joint pain, coughing, or heartburn can massively disrupt sleep.

4. Sleep Hygiene: 7 Rules for Better Sleep

Sleep hygiene is the most important non-medication measure for sleep problems — and the foundation of any effective treatment:

  1. Fixed times: Go to bed and get up at the same time every day — including weekends.
  2. Bedroom = sleep space: Use it only for sleeping. No TV, no working in bed.
  3. Screen break: Put away your smartphone and laptop 60 minutes before bed. Blue light suppresses melatonin production.
  4. Temperature: 61–64 °F (16–18 °C), well ventilated and dark.
  5. No caffeine after 2 PM: Caffeine has a half-life of 5–6 hours — afternoon coffee is still active at midnight.
  6. No alcohol as a sleep aid: Alcohol helps you fall asleep faster but massively disrupts sleep continuity through REM sleep fragmentation.
  7. Relaxation: Progressive muscle relaxation, the 4-7-8 breathing technique (inhale 4 sec, hold 7 sec, exhale 8 sec), or a body scan meditation.

5. Home Remedies and Natural Sleep Aids

Herbal preparations can provide supportive relief for mild sleep problems: valerian (as a tablet or tea — its effect builds over 2–4 weeks), hops (often combined with valerian), passionflower (particularly for stress-related difficulty falling asleep), and lavender (as an oil on the pillow or in capsule form).

Warm milk with honey is a classic remedy — the effect is more psychological than pharmacological, but bedtime rituals genuinely help with sleep onset. Tart cherry juice contains natural melatonin and may provide supportive benefit.

Melatonin: what's available? In many countries, low-dose melatonin (up to 1–2 mg) is available over the counter as a food supplement. Higher doses may require a prescription. Melatonin is not a conventional sleeping tablet — it supports the natural sleep-wake rhythm, and is particularly helpful for jet lag and shift work.

6. Could Your Medication Be the Cause?

Digital medication plan: Record all your medications — your doctor can immediately identify sleep-disrupting active substances.

Interaction check: Taking several stimulating medications at once? brite shows you the combination instantly.

Dose reminder: Taking prednisolone and torasemide in the morning rather than the evening makes a real difference to your sleep.

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7. When Should You Have Sleep Problems Investigated?

  • Sleep problems lasting more than 4 weeks despite good sleep hygiene.
  • Extreme daytime sleepiness with microsleep episodes or concentration loss.
  • Loud snoring with breathing pauses (ask your partner!).
  • Sleep problems coinciding with a new medication.
  • Low mood, hopelessness — Samaritans: 116 123 (free, 24/7).

8. Preparing for Your Doctor's Appointment — Your Checklist

  • Sleep pattern: Difficulty falling asleep, staying asleep, or early waking?
  • Since when? And what has changed (stress, medications, life circumstances)?
  • Medications: Complete list — including over-the-counter products and vitamins.
  • Sleep hygiene: Sleep times, screen time, caffeine, alcohol?
  • Associated symptoms: Snoring, breathing pauses, heart palpitations, pain?

How brite helps you stay on top of it all

brite helps you identify sleep-disrupting medications and maintain the right timing for your doses.

  • Digital medication plan – All your preparations at a glance, making sleep-disrupting active substances immediately visible. To the medication plan
  • Interaction check – Flags immediately when multiple stimulating medications are being combined. Check now
  • Dose reminder – Taking prednisolone and torasemide in the morning makes a decisive difference for your sleep. Set up reminder
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brite App – Medication plan and interaction check

FAQ: Frequently Asked Questions About Sleep Problems

Yes. Bisoprolol and metoprolol suppress the body's own melatonin production and can cause sleep disturbances, vivid dreams, and night-time waking. Speak to your doctor — a melatonin supplement in the evening sometimes helps.
Prednisolone activates the metabolism and has a stimulating effect. For this reason, cortisone should be taken in the morning wherever possible — taking it in the evening leads to insomnia.
In many countries, low-dose melatonin is available over the counter as a food supplement. Higher-dose preparations may require a prescription. Melatonin supports the natural sleep-wake rhythm — particularly helpful for jet lag and shift work.
Benzodiazepines and Z-drugs (zopiclone, zolpidem) can cause dependence after just 2–4 weeks. Use short-term only. Long-term, cognitive behavioural therapy for insomnia (CBT-I) is the most effective treatment.
Yes. Overdosing acts like an overactive thyroid: heart palpitations, restlessness, sweating, and insomnia. Regular TSH monitoring via a blood test is important.

Sources

  1. NICE: Insomnia — clinical guideline CG192 (2015, updated 2021)
  2. Wafford KA et al.: Beta-blockers and sleep. Ther Adv Psychopharmacol 2013
  3. Prescribing information: bisoprolol, prednisolone, levothyroxine, torasemide (2024)
  4. van Maanen A et al.: Melatonin for circadian sleep disorders. Cochrane 2016
  5. brite App: Anonymised user data, as of February 2026
Medical disclaimer: This page is for general informational purposes only and does not replace medical advice. For persistent insomnia, extreme exhaustion, or psychological distress, please seek medical help. Samaritans: 116 123. Last updated: February 2026.