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At a glance
Record how your pain, leg circumference and treatment develop — free in the brite app.
Lipoedema is a chronic disorder of fat distribution: the fatty tissue under the skin of the legs — and often the arms as well — increases symmetrically and out of proportion to the rest of the body. What matters for the diagnosis is not just the shape but the pain: the affected areas hurt when pressed or touched, feel heavy and bruise easily.¹
The name is somewhat misleading. “Oedema” means fluid retention, yet according to the current guideline, swelling caused by fluid in the tissue is not necessarily part of the condition. At its core, it is about an increase in painful fatty tissue.¹ The hands and feet typically stay slim — which often creates a visible “cuff” at the ankles and wrists.
Lipoedema affects almost exclusively women and usually begins during phases of hormonal change: in puberty, after a pregnancy or during the menopause. How common it is cannot be said reliably. Published estimates vary widely, because uniform diagnostic criteria were lacking for a long time and lipoedema is easily mistaken for excess weight.¹
Doctors describe lipoedema in three stages based on the appearance of the skin and the tissue beneath it. This classification is also reflected in the ICD-10 codes.¹,²
| Stage | Skin surface | On palpation |
|---|---|---|
| Stage I (E88.20) | Smooth, even | Subcutaneous tissue thickened, finely nodular |
| Stage II (E88.21) | Uneven, wavy, “mattress skin” | Coarsely nodular structures |
| Stage III (E88.22) | Pronounced bulges and overhanging folds of tissue, especially on the inner knees and thighs | Firm, with large lobes |
Important: the stage says little about how severe the symptoms are. Some women in stage I have considerable pain, while others in stage III have comparatively little. The guideline therefore puts pain and limitations in everyday life at the centre — not the stage alone.¹ According to current knowledge, there is no evidence that lipoedema inevitably progresses from one stage to the next.
Doctors also describe where the fat is located: on the thighs and hips (“riding breeches” type), on the whole leg or mainly on the lower leg. In some people the arms are also affected, but almost never on their own.
The typical picture is a combination of shape and pain:¹
When the condition is pronounced, the thighs rub together, the skin becomes sore, walking becomes an effort and the knee joints are put under abnormal strain. For many, the emotional side weighs at least as heavily: being told for years that you “just need to eat less”, even though diets barely change the legs, is wearing. Low mood and disordered eating are more common with lipoedema.¹ This is a part of the condition that deserves to be taken seriously — more on this under depression.
The exact cause is not known. Several factors that interact are being discussed:¹
Lipoedema is diagnosed clinically — that is, through a consultation, a visual examination and palpation. There is no laboratory or imaging test that proves it. It is mainly assessed by specialist practices for angiology, phlebology and lymphology.¹
The main conditions to rule out are obesity, lymphoedema (usually asymmetrical, with a swollen top of the foot), venous insufficiency with varicose veins, an underactive thyroid and painless lipohypertrophy — the same fat distribution without pain, which is not considered a disease. A sudden, one-sided swelling with pain in the calf, on the other hand, is never lipoedema: thrombosis must be ruled out immediately.
Before your appointment, note down how long you have had the symptoms and what you have already tried — tips in the guide Preparing for a doctor's appointment.
Lipoedema cannot be cured. The aim of treatment is to relieve pain and heaviness, maintain mobility and prevent secondary damage. The guideline relies on several complementary components for this — and on self-management by those affected.¹
To be honest: conservative treatment usually does not make the legs smaller. It can, however, noticeably relieve pain and is a prerequisite before surgery can be covered by statutory health insurance. The treating practice decides together with you which combination is right.¹,³
According to current knowledge, there is no medicine that specifically targets lipoedema. Medications still play a role, though — mainly because some cause harm and others can help with accompanying conditions.¹
| Remedy | Assessment based on current knowledge |
|---|---|
| Water tablets (diuretics) such as furosemide | Not effective against lipoedema fat; long-term use risks electrolyte imbalances and circulatory problems. Only for a different, confirmed indication |
| Painkillers | No specific effect on lipoedema pain has been demonstrated; if needed, short-term use after discussion with your doctor — see Painkillers compared |
| Weight-loss injections such as semaglutide or tirzepatide | Approved for weight reduction in obesity, not for lipoedema. They can reduce the share attributable to excess weight; whether lipoedema fat also decreases has not been adequately studied |
| Vein remedies, enzyme preparations, dietary supplements | No robust evidence of effectiveness in lipoedema |
Weight-loss injections are a topic for many people with lipoedema. According to the product information, they are approved for adults with obesity, or with excess weight and weight-related conditions, always in addition to dietary changes and exercise.⁴ Statutory health insurance generally does not cover the costs for weight reduction. The guide Weight-loss injections compared gives an overview.
brite reminds you to take your medications and shows which remedies are compatible with your long-term medication.
Liposuction is the only treatment that actually removes the abnormally increased fatty tissue. It is performed under local anaesthetic with large volumes of fluid (tumescent technique) or under general anaesthetic, usually over several sessions. Special tissue-sparing techniques are used to protect the lymphatic vessels.¹
For a long time, statutory health insurance only paid for liposuction in stage III. Following a trial study, the Federal Joint Committee (G-BA, the body that decides which treatments statutory health insurance covers) decided in July 2025 to include it in the benefits catalogue regardless of stage — subject to conditions:³
It is best to clarify the exact requirements for your individual case with the treating practice and your health insurance fund before an appointment is scheduled.
Many people report significantly less pain and better mobility after liposuction; the results of the trial study formed the basis for extending cost coverage.³ However, surgery is not a substitute for everything else: for many, compression remains useful — at least at times — and later weight gain can reduce the effect. Long-term data over many years are still limited.¹
Risks include bruising, swelling, infections, dents and unevenness, altered skin sensation and — rarely, but seriously — thrombosis and pulmonary embolism. Compression garments are worn for several weeks after the procedure. Which medications are paused before surgery, such as blood thinners or oestrogen-containing preparations, is decided by the surgical team — more in the guide Medications before surgery.
Lipoedema and obesity often occur together, and that is more than a detail: excess weight increases volume, pain and strain on the joints, and the fat distribution shifts. The guideline therefore recommends that any additional excess weight is treated as well — not as a reproach, but because it affects the symptoms.¹
If your BMI is markedly raised, nutrition and exercise programmes, weight-loss medication or obesity surgery may be options. The treating practice makes this decision together with you.
Also keep track of all your products, including over-the-counter medicines and dietary supplements — you can find a template in the guide Creating a medication plan.
Record pain scores, weight and compression times as you go, instead of gathering them together for the application.
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