Coronary Heart Disease (CHD):
Symptoms, Treatment & Prevention

At a glance

FrequencyOne of the most common causes of death worldwide
What happensNarrowing of the coronary arteries due to atherosclerosis — the heart receives too little oxygen
Leading symptomAngina pectoris — tightness, pressure or pain in the chest, often on exertion
TreatmentLifestyle changes, medications (statins, aspirin, beta-blockers and others), stent or bypass surgery when needed
GuidelineESC Chronic Coronary Syndromes 2024; NICE NG185
ICD-10I25 (Chronic ischaemic heart disease), I20 (Angina pectoris)

1. What is CHD?

In coronary heart disease (CHD), the coronary arteries are narrowed by deposits in the vessel walls (atherosclerosis, plaques). As a result, the heart muscle receives too little oxygen on exertion — or, in severe cases, even at rest.¹

CHD is one of the most common causes of death worldwide. The condition typically develops over decades and is promoted by the classic cardiovascular risk factors: elevated cholesterol, high blood pressure, diabetes, smoking.¹,²

Well manageable — prognosis can be substantially improved CHD is generally well manageable. Modern medications, lifestyle changes and, when needed, interventional procedures (stent, bypass) can substantially improve prognosis and prevent heart attacks.

2. Symptoms

Angina pectoris (chest tightness)

  • Pressure, tightness or pain in the chest — the leading symptom
  • Typically occurs with physical exertion, stress or cold and improves at rest
  • Possible radiation to: left arm, jaw, back, upper abdomen
  • Shortness of breath on exertion

Atypical symptoms

Particularly in women, older people and people with diabetes, CHD can present atypically:

  • Shortness of breath without chest pain
  • Unusual fatigue
  • Upper abdominal symptoms, nausea
  • Reduced exercise capacity
Heart attack warning — call emergency services immediately Sudden, severe chest pain lasting longer than five minutes, with radiation, cold sweats, shortness of breath or feeling of dread — call emergency services immediately. Every minute counts.

3. Risk factors

Most risk factors for CHD are modifiable.¹

Modifiable

  • High LDL cholesterol — the most important modifiable risk factor
  • High blood pressure
  • Smoking — one of the strongest risk factors; stopping smoking reduces risk quickly and substantially
  • Diabetes — substantially increases CHD risk
  • Obesity and lack of exercise
  • Unhealthy diet

Non-modifiable

  • Age — risk rises with age
  • Sex — men typically develop CHD earlier; women catch up after menopause
  • Family history — heart attack in first-degree relatives at a young age

4. Diagnosis

  • History and physical examination: typical symptoms, risk factors, exertion profile.
  • Resting ECG: can be normal at rest. Shows clues to previous heart attack or rhythm disturbances.
  • Exercise ECG (ergometry): ECG under physical exertion — can detect blood-flow disturbances on exertion.
  • Echocardiography (heart ultrasound): assesses heart function, heart valves and wall motion abnormalities.
  • Stress imaging: stress MRI or myocardial scintigraphy — can show blood-flow disturbances more accurately than the exercise ECG.
  • CT coronary angiography: non-invasive imaging of the coronary arteries. Can rule out CHD with high reliability.
  • Cardiac catheterisation (invasive coronary angiography): the gold standard for visualising the coronary arteries. Typically performed when an intervention (stent) is planned or when non-invasive imaging was inconclusive.
  • Laboratory: lipid profile (LDL, HDL, triglycerides), blood glucose/HbA1c, kidney values, troponin (when heart attack is suspected).

5. Treatment: medications

Medications form the foundation of CHD treatment — they reduce the risk of heart attack and improve prognosis.¹

Foundation Lipid lowering & antiplatelet therapy
Statins
Lower LDL cholesterol and have been shown to reduce the risk of heart attack and cardiovascular death. Standard therapy in CHD.
Antiplatelet therapy
Aspirin in low dose — inhibits platelet clumping and reduces the risk of heart attack. Standard therapy for known CHD. After a stent, time-limited dual antiplatelet therapy (aspirin + a P2Y12 inhibitor such as clopidogrel or ticagrelor) is typically used.
Circulation Beta-blockers, ACE inhibitors, ARBs
Beta-blockers
Lower the heart rate and blood pressure. Used for angina pectoris and after a heart attack.
ACE inhibitors / ARBs
Protect heart and vessels. Particularly recommended with concomitant high blood pressure, heart failure or diabetes.
Acute Nitrates (as needed)
Glyceryl trinitrate (GTN) spray
Dilates the coronary arteries and can relieve an acute angina attack. Used as needed.
Add-on Other agents

Depending on individual risk and comorbidities: calcium channel blockers, ranolazine, ezetimibe, PCSK9 inhibitors, bempedoic acid.


6. Treatment: stent and bypass

Stent (percutaneous coronary intervention, PCI)

A small wire mesh is inserted via cardiac catheter into the narrowed vessel and expands it. Drug-eluting stents (DES) are typically used. The procedure is usually performed via the wrist artery and is typically minimally invasive.

Bypass surgery

A surgical procedure where narrowed coronary arteries are bypassed using the patient's own vessels (internal mammary artery, leg vein). Typically recommended for severe multi-vessel disease or left main stenosis.

The procedure does not replace medications Stent and bypass treat the narrowing but not the underlying disease (atherosclerosis). Medications and lifestyle changes remain permanently necessary even after a procedure.

7. Lifestyle

Lifestyle changes are a central component of CHD treatment — they can substantially improve prognosis.¹

  • Stop smoking — the most effective single measure; risk falls within the first weeks after stopping
  • Regular exercise — moderate aerobic exercise, typically at least five times per week; cardiac rehabilitation programmes offer a structured programme
  • Heart-healthy diet — Mediterranean diet: plenty of vegetables, fruit, pulses, nuts, olive oil, fish; little saturated fat, sugar and salt
  • Weight control — reduce excess weight
  • Stress management — relaxation techniques, adequate sleep
  • Reduce alcohol intake

8. Heart attack — recognising the emergency

A heart attack occurs when a coronary artery is suddenly completely blocked (typically by a plaque rupture and clot formation). The heart muscle no longer receives oxygen — every minute counts.

Warning signs

  • Severe, persistent chest pain (longer than five minutes) — pressure, tightness, burning
  • Radiation to left arm, jaw, back, upper abdomen
  • Cold sweats, pale skin
  • Shortness of breath
  • Feeling of dread, sense of impending doom
  • In women often atypical: nausea, upper abdominal pain, shortness of breath without typical chest pain
If a heart attack is suspected: call emergency services immediately Do not wait. Do not drive yourself. Every minute of delay costs heart muscle tissue. Emergency services dispatch an ambulance with paramedics — first-line care begins immediately.

How brite helps you with CHD

Statin in the evening, aspirin in the morning, beta-blocker alongside, ACE inhibitor separately — and after a stent, a second antiplatelet for a defined period. CHD treatment is teamwork between many medications over a long time. brite holds the plan together.

  • Intake reminder — statin, aspirin, beta-blocker, ACE inhibitor on time. Particularly with dual antiplatelet therapy after a stent, reliable intake is crucial to prevent stent thrombosis.
  • Drug interaction check — aspirin plus an NSAID (e.g. ibuprofen, can increase bleeding risk)? Statin plus grapefruit or a macrolide antibiotic? Clopidogrel plus a proton pump inhibitor? brite shows what may be problematic.
  • Health journal — track blood pressure, LDL, blood glucose and exercise capacity over time. So at the next appointment it's easy to show whether treatment goals are being met — or whether an adjustment is needed.
  • Digital medication plan — all medications clearly organised for cardiology, GP, rehabilitation and emergency care. In an emergency (e.g. suspected heart attack), paramedics see immediately which medications are being taken.
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FAQ: Common questions about CHD

Angina pectoris is a temporary blood-flow disturbance — symptoms occur on exertion and improve at rest. In a heart attack, a coronary artery is completely blocked — symptoms persist and do not improve. A heart attack is an emergency (call emergency services immediately).
Generally yes. CHD is a chronic condition. Medications such as statins and aspirin durably reduce the risk of heart attack and cardiovascular death. They should not be stopped on your own.
Yes — regular moderate exercise is explicitly recommended and improves prognosis. Cardiac rehabilitation programmes offer supervised exercise. Exercise intensity should be coordinated with cardiology.
A small wire mesh inserted via cardiac catheter into a narrowed coronary artery to keep it open. After a stent, time-limited dual antiplatelet therapy (aspirin + a second agent) is typically required.
Lifestyle changes (diet, exercise, stopping smoking) can slow the progression of atherosclerosis and lower the risk of heart attack. Complete reversal of existing plaques is typically not realistic — but stabilisation and risk reduction certainly are.
A surgical procedure where narrowed coronary arteries are bypassed using the patient's own vessels. Typically recommended for severe multi-vessel disease when a stent is insufficient. The procedure is bigger than stent implantation but offers better long-term results in certain situations.
For severe chest pain lasting longer than five minutes, with radiation, cold sweats, shortness of breath or feeling of dread — call emergency services immediately. With atypical symptoms (nausea, upper abdominal pain, shortness of breath), when in doubt it's better to call once too often.
Women typically develop CHD later than men (after menopause) but more often present with atypical symptoms (nausea, upper abdominal pain, shortness of breath instead of typical chest pain). As a result, heart attacks in women are more often recognised late.

Sources

  1. ESC Guidelines for Chronic Coronary Syndromes (2024 Update). escardio.org
  2. NICE Guideline NG185: Acute coronary syndromes. nice.org.uk
  3. NVL Chronische KHK (BÄK/KBV/AWMF, 6th edition 2022, AWMF nvl-004). leitlinien.de
  4. British Heart Foundation: Coronary heart disease. bhf.org.uk
Medical disclaimer: This article is for general information only and does not replace medical advice, diagnosis or treatment. If a heart attack is suspected, call emergency services immediately. CHD medications should not be stopped or adjusted on your own. Treatment planning is always determined individually by the treating cardiology or general practice. Last updated: April 2026.