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Medically reviewed guide · Last updated: 1 September 2026 · Reading time: approx. 10 min
At a glance
| Cause | When it occurs | Typical accompanying signs | First step |
|---|---|---|---|
| Drop in blood pressure on standing | Seconds to three minutes after standing up, after large meals, in the heat | Vision going black, weak knees, rushing in the ears; better when lying down | Stand up slowly, drink; standing test with blood pressure measurement |
| Blood pressure medicines, water tablets and prostate medicines | After starting treatment or increasing the dose, often a few hours after taking them | Low readings in your log; diarrhoea or heat make it worse | Keep a blood pressure log, discuss with your practice |
| Sleeping pills, sedatives and painkillers | In the morning after taking them the evening before, after a dose increase | Tiredness, slowed thinking, unsteady walking | Have your medicines reviewed, no alcohol with them |
| Low blood sugar | With insulin or sulfonylureas, after exercise or a missed meal | Sweating, trembling, ravenous hunger, palpitations | Measure your blood sugar, take fast-acting carbohydrates |
| Heart rhythm, anaemia | On exertion or in sudden attacks | Skipped beats, racing heart, very slow pulse, breathlessness, pallor | ECG and blood count at the practice |
| Anxiety, hyperventilation, exhaustion | In stressful situations or constantly, "as if behind glass" | Tingling around the mouth, tight chest, palpitations | Breathe out slowly; seek help if the strain is ongoing |
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In everyday language, "dizziness" covers very different sensations. If your surroundings are spinning, there is usually a problem with the balance organ — that is covered in the articles on dizziness and balance disorders. This article is about the other feeling: lightheaded, empty-headed, "as if wrapped in cotton wool", sometimes with the sense that you are about to keel over. Doctors call this lightheadedness or, when fainting is imminent, presyncope. How medicines in general can trigger dizziness is described in the complementary guide Dizziness from medications.
When you stand up, some of your blood pools in your legs and abdomen. Normally the body compensates within seconds by narrowing the blood vessels and making the heart beat faster. If that does not work, blood pressure falls and the brain briefly gets too little blood: your vision goes black, your knees go weak and there is a rushing sound in your ears. Doctors speak of orthostatic hypotension when, within three minutes of standing, the upper (systolic) reading falls by at least 20 mmHg or the lower (diastolic) reading by at least 10 mmHg.
This is made more likely by a lack of fluids in the heat or with diarrhoea or fever, by alcohol, long periods of bed rest, older age and conditions that damage the nerves controlling the circulation, such as long-standing diabetes or Parkinson's disease. Older people often experience the drop after a large meal (postprandial hypotension). In young people, it is sometimes not the blood pressure that falls but the pulse that rises sharply on standing — a sign of postural tachycardia syndrome (POTS), which can also appear after infections. More on persistently low readings in the article on low blood pressure; if you actually pass out, the article on fainting will help.
If lightheadedness appears after a new medicine or an increase in dose, a link is likely. Two mechanisms dominate: active substances that lower blood pressure intensify the drop on standing, and sedating active substances slow the brain down. The two add up when several medicines come together — typically in older people with long medication plans. Which active substances are particularly likely to be involved is set out below in the medication section.
If you take insulin or sulfonylureas such as glimepiride, you can develop low blood sugar (hypoglycaemia) — after exercise, a missed meal, alcohol or too high a dose. As a rule, a reading below 70 mg/dl (3.9 mmol/l) counts as low blood sugar. The first signs are sweating, trembling, palpitations and ravenous hunger, followed by lightheadedness, poor concentration and confusion. Beta blockers can dampen trembling and palpitations, so that the warning signs are missing. People who do not take diabetes medicines rarely experience true hypoglycaemia; the queasy feeling after a long fast usually has other causes.
If the heart pumps too slowly, too fast or irregularly, blood flow to the brain decreases. Sudden attacks of lightheadedness with a racing heart or skipped beats can point to rhythm disorders such as atrial fibrillation, and a very slow pulse to conduction disorders or too high a dose of beta blockers. In older people, lightheadedness on exertion, with breathlessness or chest tightness, can point to a narrowed heart valve (aortic stenosis). Anaemia shows itself through pallor, tiredness and lightheadedness, especially on exertion.
During anxiety and panic, many people breathe too fast without noticing. This lowers the carbon dioxide level in the blood, the blood vessels in the brain narrow slightly, and lightheadedness develops, with tingling around the mouth and in the hands, a tight chest and the feeling of standing "beside yourself" or "behind glass". In panic disorder, this can be so frightening that it triggers new anxiety in itself.
If non-specific lightheadedness or unsteadiness persists on most days for more than three months, worse when standing, when moving and in visually busy surroundings such as a supermarket or when scrolling, persistent postural-perceptual dizziness (PPPD) may be the cause. It often develops after an acute episode of vertigo, a panic attack or concussion, and it responds well to treatment — with balance training, behavioural therapy and medication if needed.
Too little or poor sleep, untreated sleep apnoea, fever, lack of fluids and the day after alcohol or cannabis often leave you lightheaded. In older people, a low sodium level in the blood (hyponatraemia) is an underestimated cause: it shows itself through lightheadedness, confusion and falls, and is often encouraged by water tablets or certain antidepressants — a simple blood test will clarify it. After a viral infection, including COVID-19, some people report weeks of lightheadedness and problems concentrating.
A stroke in the posterior circulation of the brain can begin with sudden dizziness or lightheadedness — usually together with double vision, slurred speech, difficulty swallowing, unsteady walking or weakness on one side. And lightheadedness with chest pressure, shortness of breath or a cold sweat can be a heart attack. In both cases, every minute counts.
These tests do not replace a diagnosis. Only do them when you are feeling well, and only do the standing test with a second person nearby.
Lightheadedness is one of the most common side effects of all. The following groups are involved particularly often.
Any blood pressure medicine can make you lightheaded, especially at the start, after dose increases, in the heat, and with diarrhoea and vomiting. ACE inhibitors such as ramipril and sartans (angiotensin receptor blockers) can lower blood pressure sharply, especially with the first dose and above all in combination with water tablets. Water tablets in turn remove fluid and salt from the body, which in older people can lead to hyponatraemia. Beta blockers slow the pulse, while alpha blockers such as doxazosin and prostate medicines such as tamsulosin encourage the drop in blood pressure on standing. Nitrates and erectile dysfunction medicines must never be combined. Ask your practice in advance how to handle water tablets and blood pressure medicines if you have diarrhoea or a fever.
Benzodiazepines such as lorazepam or diazepam and Z-drugs such as zolpidem can still have an effect the next day: lightheadedness, slowed reactions, unsteady walking. Alcohol makes this considerably worse. Over-the-counter sleeping aids containing diphenhydramine or doxylamine also have anticholinergic effects and, according to the PRISCUS list (the German list of potentially inappropriate medicines for older people), are unsuitable for older people. After taking benzodiazepines for a longer period, you must not stop them abruptly. Alternatives are described in the guide Alternatives to sedatives.
Tricyclic antidepressants such as amitriptyline, as well as mirtazapine and quetiapine, cause tiredness and lower blood pressure on standing. SSRIs can cause lightheadedness at the start and when stopped too quickly, and in older people they can lower the sodium level. With pregabalin and gabapentin, lightheadedness and drowsiness are among the very common side effects, especially while the dose is being increased.
Opioids such as tramadol or tilidine cause lightheadedness especially at the start. Muscle relaxants and anticholinergic bladder medicines can trigger lightheadedness and confusion in older people. Insulin and sulfonylureas cause low blood sugar, and SGLT2 inhibitors such as empagliflozin can lower blood pressure through fluid loss, especially together with water tablets.
Ibuprofen and other anti-inflammatory painkillers rarely cause lightheadedness themselves, but they weaken the effect of blood pressure medicines and, together with ACE inhibitors or sartans and water tablets, put a strain on the kidneys. Without medical advice, the package leaflet usually says: no longer than three to four days in a row.
With every additional sedating or blood pressure-lowering medicine, the risk of falling rises. The PRISCUS 2.0 list names active substances that are particularly unfavourable for older people. That is why any long-term medication in older age should be reviewed regularly.
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This article is for general information and does not replace medical advice, diagnosis or treatment. The self-tests described — including the standing test — are a guide and not a diagnosis. If you have lightheadedness with chest pain, shortness of breath, a racing heart or loss of consciousness, sudden double vision, difficulty speaking or paralysis, or severe low blood sugar, please contact a doctor or the emergency services without delay.